| 2X2 | 361 | Lightning Bolt | Instant | | |
| 2X2 | 362 | Monastery Swiftspear | Creature — Human Monk | | |
| 2X2 | 363 | Seasoned Pyromancer | Creature — Human Shaman | | |
| 2X2 | 364 | Young Pyromancer | Creature — Human Shaman | | |
| 2X2 | 365 | Allosaurus Shepherd | Creature — Elf Shaman | | |
| 2X2 | 366 | Bloom Tender | Creature — Elf Druid | | |
| 2X2 | 367 | Concordant Crossroads | World Enchantment | | |
| 2X2 | 368 | Eternal Witness | Creature — Human Shaman | | |
| 2X2 | 369 | Hardened Scales | Enchantment | | |
| 2X2 | 370 | Oracle of Mul Daya | Creature — Elf Shaman | | |
| 2X2 | 371 | Rampant Growth | Sorcery | | |
| 2X2 | 372 | Assassin's Trophy | Instant | | |
| 2X2 | 373 | Bloodbraid Elf | Creature — Elf Berserker | | |
| 2X2 | 374 | Burning-Tree Emissary | Creature — Human Shaman | | |
| 2X2 | 375 | Coiling Oracle | Creature — Snake Elf Druid | | |
| 2X2 | 376 | Dragonlord Dromoka | Legendary Creature — Elder Dragon | | |
| 2X2 | 377 | Elenda, the Dusk Rose | Legendary Creature — Vampire Knight | | |
| 2X2 | 378 | Glimpse the Unthinkable | Sorcery | | |
| 2X2 | 379 | Grand Arbiter Augustin IV | Legendary Creature — Human Advisor | | |
| 2X2 | 380 | Grim Flayer | Creature — Human Warrior | | |
| 2X2 | 381 | Kolaghan's Command | Instant | | |
| 2X2 | 382 | Marchesa, the Black Rose | Legendary Creature — Human Wizard | | |
| 2X2 | 383 | The Mimeoplasm | Legendary Creature — Ooze | | |
| 2X2 | 384 | Muldrotha, the Gravetide | Legendary Creature — Elemental Avatar | | |
| 2X2 | 385 | Privileged Position | Enchantment | | |
| 2X2 | 386 | Qasali Pridemage | Creature — Cat Wizard | | |
| 2X2 | 387 | Sedris, the Traitor King | Legendary Creature — Zombie Warrior | | |
| 2X2 | 388 | Supreme Verdict | Sorcery | | |
| 2X2 | 389 | Terminate | Instant | | |
| 2X2 | 390 | Thousand-Year Storm | Enchantment | | |
| 2X2 | 391 | Aether Vial | Artifact | | |
| 2X2 | 392 | Bloodforged Battle-Axe | Artifact — Equipment | | |
| 2X2 | 393 | Crucible of Worlds | Artifact | | |
| 2X2 | 394 | Mana Vault | Artifact | | |
| 2X2 | 395 | Panharmonicon | Artifact | | |
| 2X2 | 396 | Phyrexian Altar | Artifact | | |
| 2X2 | 397 | Pithing Needle | Artifact | | |
| 2X2 | 398 | Sensei's Divining Top | Artifact | | |
| 2X2 | 399 | Vedalken Orrery | Artifact | | |
| 2X2 | 400 | Azorius Chancery | Land | | |
| 2X2 | 401 | Boros Garrison | Land | | |
| 2X2 | 402 | Cavern of Souls | Land | | |
| 2X2 | 403 | City of Brass | Land | | |
| 2X2 | 404 | Dimir Aqueduct | Land | | |
| 2X2 | 405 | Forbidden Orchard | Land | | |
| 2X2 | 406 | Golgari Rot Farm | Land | | |
| 2X2 | 407 | Gruul Turf | Land | | |
| 2X2 | 408 | Izzet Boilerworks | Land | | |
| 2X2 | 409 | Orzhov Basilica | Land | | |
| 2X2 | 410 | Rakdos Carnarium | Land | | |
| 2X2 | 411 | Selesnya Sanctuary | Land | | |
| 2X2 | 412 | Simic Growth Chamber | Land | | |
| 2X2 | 413 | Emrakul, the Aeons Torn | Legendary Creature — Eldrazi | | |
| 2X2 | 414 | Kozilek, Butcher of Truth | Legendary Creature — Eldrazi | | |
| 2X2 | 415 | Ulamog, the Infinite Gyre | Legendary Creature — Eldrazi | | |
| 2X2 | 416 | Divine Visitation | Enchantment | | |
| 2X2 | 417 | Emiel the Blessed | Legendary Creature — Unicorn | | |
| 2X2 | 418 | Leonin Arbiter | Creature — Cat Cleric | | |
| 2X2 | 419 | Mikaeus, the Lunarch | Legendary Creature — Human Cleric | | |
| 2X2 | 420 | Monastery Mentor | Creature — Human Monk | | |