| 2X2 | 421 | Restoration Angel | Creature — Angel | | |
| 2X2 | 422 | Reveillark | Creature — Elemental | | |
| 2X2 | 423 | Smothering Tithe | Enchantment | | |
| 2X2 | 424 | Teferi's Protection | Instant | | |
| 2X2 | 425 | Weathered Wayfarer | Creature — Human Nomad Cleric | | |
| 2X2 | 426 | As Foretold | Enchantment | | |
| 2X2 | 427 | Consecrated Sphinx | Creature — Sphinx | | |
| 2X2 | 428 | Disciple of the Ring | Creature — Human Wizard | | |
| 2X2 | 429 | Force of Negation | Instant | | |
| 2X2 | 430 | Gifts Ungiven | Instant | | |
| 2X2 | 431 | Kederekt Leviathan | Creature — Leviathan | | |
| 2X2 | 432 | Mana Drain | Instant | | |
| 2X2 | 433 | Pull from Tomorrow | Instant | | |
| 2X2 | 434 | Talrand, Sky Summoner | Legendary Creature — Merfolk Wizard | | |
| 2X2 | 435 | Venser, Shaper Savant | Legendary Creature — Human Wizard | | |
| 2X2 | 436 | Bitterblossom | Kindred Enchantment — Faerie | | |
| 2X2 | 437 | Damnation | Sorcery | | |
| 2X2 | 438 | Gravecrawler | Creature — Zombie | | |
| 2X2 | 439 | Imperial Seal | Sorcery | | |
| 2X2 | 440 | Liliana, the Last Hope | Legendary Planeswalker — Liliana | | |
| 2X2 | 441 | Necrotic Ooze | Creature — Ooze | | |
| 2X2 | 442 | Ob Nixilis, Unshackled | Legendary Creature — Demon | | |
| 2X2 | 443 | Oona's Prowler | Creature — Faerie Rogue | | |
| 2X2 | 444 | Surgical Extraction | Instant | | |
| 2X2 | 445 | Yahenni, Undying Partisan | Legendary Creature — Aetherborn Vampire | | |
| 2X2 | 446 | Abbot of Keral Keep | Creature — Human Monk | | |
| 2X2 | 447 | Alesha, Who Smiles at Death | Legendary Creature — Human Warrior | | |
| 2X2 | 448 | Anger of the Gods | Sorcery | | |
| 2X2 | 449 | Backdraft Hellkite | Creature — Dragon | | |
| 2X2 | 450 | Bedlam Reveler | Creature — Devil Horror | | |
| 2X2 | 451 | Chaos Warp | Instant | | |
| 2X2 | 452 | Dockside Extortionist | Creature — Goblin Pirate | | |
| 2X2 | 453 | Greater Gargadon | Creature — Beast | | |
| 2X2 | 454 | Seasoned Pyromancer | Creature — Human Shaman | | |
| 2X2 | 455 | Twinflame | Sorcery | | |
| 2X2 | 456 | Warrior's Oath | Sorcery | | |
| 2X2 | 457 | Allosaurus Shepherd | Creature — Elf Shaman | | |
| 2X2 | 458 | Bloom Tender | Creature — Elf Druid | | |
| 2X2 | 459 | Concordant Crossroads | World Enchantment | | |
| 2X2 | 460 | Food Chain | Enchantment | | |
| 2X2 | 461 | Green Sun's Zenith | Sorcery | | |
| 2X2 | 462 | Hardened Scales | Enchantment | | |
| 2X2 | 463 | Impervious Greatwurm | Creature — Wurm | | |
| 2X2 | 464 | Oracle of Mul Daya | Creature — Elf Shaman | | |
| 2X2 | 465 | Rishkar, Peema Renegade | Legendary Creature — Elf Druid | | |
| 2X2 | 466 | Splinterfright | Creature — Elemental | | |
| 2X2 | 467 | Abzan Ascendancy | Enchantment | | |
| 2X2 | 468 | Aminatou, the Fateshifter | Legendary Planeswalker — Aminatou | | |
| 2X2 | 469 | Anguished Unmaking | Instant | | |
| 2X2 | 470 | Animar, Soul of Elements | Legendary Creature — Elemental | | |
| 2X2 | 471 | Arjun, the Shifting Flame | Legendary Creature — Sphinx Wizard | | |
| 2X2 | 472 | Ashen Rider | Creature — Archon | | |
| 2X2 | 473 | Ashenmoor Liege | Creature — Elemental Knight | | |
| 2X2 | 474 | Assassin's Trophy | Instant | | |
| 2X2 | 475 | Atarka's Command | Instant | | |
| 2X2 | 476 | Atla Palani, Nest Tender | Legendary Creature — Human Shaman | | |
| 2X2 | 477 | Aurelia, the Warleader | Legendary Creature — Angel | | |
| 2X2 | 478 | Balefire Liege | Creature — Spirit Horror | | |
| 2X2 | 479 | Boartusk Liege | Creature — Goblin Knight | | |
| 2X2 | 480 | Bring to Light | Sorcery | | |