| 2X2 | 541 | Supreme Verdict | Sorcery | | |
| 2X2 | 542 | Tariel, Reckoner of Souls | Legendary Creature — Angel | | |
| 2X2 | 543 | Teneb, the Harvester | Legendary Creature — Dragon | | |
| 2X2 | 544 | Thistledown Liege | Creature — Kithkin Knight | | |
| 2X2 | 545 | Thousand-Year Storm | Enchantment | | |
| 2X2 | 546 | Thraximundar | Legendary Creature — Zombie Assassin | | |
| 2X2 | 547 | Ulasht, the Hate Seed | Legendary Creature — Hellion Hydra | | |
| 2X2 | 548 | Uril, the Miststalker | Legendary Creature — Beast | | |
| 2X2 | 549 | Varina, Lich Queen | Legendary Creature — Zombie Wizard | | |
| 2X2 | 550 | Villainous Wealth | Sorcery | | |
| 2X2 | 551 | Wasitora, Nekoru Queen | Legendary Creature — Cat Dragon | | |
| 2X2 | 552 | Wilt-Leaf Liege | Creature — Elf Knight | | |
| 2X2 | 553 | Wrenn and Six | Legendary Planeswalker — Wrenn | | |
| 2X2 | 554 | Zur the Enchanter | Legendary Creature — Human Wizard | | |
| 2X2 | 555 | Aether Vial | Artifact | | |
| 2X2 | 556 | Bloodforged Battle-Axe | Artifact — Equipment | | |
| 2X2 | 557 | Conqueror's Flail | Artifact — Equipment | | |
| 2X2 | 558 | Crucible of Worlds | Artifact | | |
| 2X2 | 559 | Darksteel Plate | Artifact — Equipment | | |
| 2X2 | 560 | Mana Vault | Artifact | | |
| 2X2 | 561 | Nim Deathmantle | Artifact — Equipment | | |
| 2X2 | 562 | Panharmonicon | Artifact | | |
| 2X2 | 563 | Phyrexian Altar | Artifact | | |
| 2X2 | 564 | Pithing Needle | Artifact | | |
| 2X2 | 565 | Planar Bridge | Legendary Artifact | | |
| 2X2 | 566 | Sensei's Divining Top | Artifact | | |
| 2X2 | 567 | Thrumming Stone | Legendary Artifact | | |
| 2X2 | 568 | Vedalken Orrery | Artifact | | |
| 2X2 | 569 | Cavern of Souls | Land | | |
| 2X2 | 570 | City of Brass | Land | | |
| 2X2 | 571 | Forbidden Orchard | Land | | |
| 2X2 | 572 | Pillar of the Paruns | Land | | |
| 2X2 | 573 | Liliana, the Last Hope | Legendary Planeswalker — Liliana | | |
| 2X2 | 574 | Wrenn and Six | Legendary Planeswalker — Wrenn | | |
| 2X2 | 575 | Emrakul, the Aeons Torn | Legendary Creature — Eldrazi | | |
| 2X2 | 576 | Kozilek, Butcher of Truth | Legendary Creature — Eldrazi | | |
| 2X2 | 577 | Ulamog, the Infinite Gyre | Legendary Creature — Eldrazi | | |
| 2X2 | 578 | Weathered Wayfarer | Creature — Human Nomad Cleric | | |
| 2X2 | 579 | Bring to Light | Sorcery | | |