| SPM | 241 | Spectacular Spider-Man | Legendary Creature — Spider Human Hero | | |
| SPM | 242 | The Soul Stone | Legendary Artifact — Infinity Stone | | |
| SPM | 243 | The Soul Stone | Legendary Artifact — Infinity Stone | | |
| SPM | 244 | Anti-Venom, Horrifying Healer | Legendary Creature — Symbiote Hero | | |
| SPM | 245 | Arachne, Psionic Weaver | Legendary Creature — Spider Human Hero | | |
| SPM | 246 | Friendly Neighborhood | Enchantment — Aura | | |
| SPM | 247 | Rent Is Due | Enchantment | | |
| SPM | 248 | With Great Power . . . | Enchantment — Aura | | |
| SPM | 249 | Hide on the Ceiling | Instant | | |
| SPM | 250 | Hydro-Man, Fluid Felon | Legendary Creature — Elemental Villain | | |
| SPM | 251 | Impostor Syndrome | Enchantment | | |
| SPM | 252 | Lady Octopus, Inspired Inventor | Legendary Creature — Human Scientist Villain | | |
| SPM | 253 | Mysterio, Master of Illusion | Legendary Creature — Human Villain | | |
| SPM | 254 | Spider-Sense | Instant | | |
| SPM | 255 | Agent Venom | Legendary Creature — Symbiote Soldier Hero | | |
| SPM | 256 | Gwenom, Remorseless | Legendary Creature — Symbiote Spider Hero | | |
| SPM | 257 | Morlun, Devourer of Spiders | Legendary Creature — Vampire Villain | | |
| SPM | 258 | Parker Luck | Enchantment | | |
| SPM | 259 | Villainous Wrath | Sorcery | | |
| SPM | 260 | Electro, Assaulting Battery | Legendary Creature — Human Villain | | |
| SPM | 261 | J. Jonah Jameson | Legendary Creature — Human Citizen | | |
| SPM | 262 | Shadow of the Goblin | Enchantment | | |
| SPM | 263 | Spider-Verse | Enchantment | | |
| SPM | 264 | Spinneret and Spiderling | Legendary Creature — Spider Human Hero | | |
| SPM | 265 | Lizard, Connors's Curse | Legendary Creature — Lizard Villain | | |
| SPM | 266 | Sandman, Shifting Scoundrel | Legendary Creature — Sand Elemental Villain | | |
| SPM | 267 | Strength of Will | Instant | | |
| SPM | 268 | Web of Life and Destiny | Enchantment | | |
| SPM | 269 | Biorganic Carapace | Artifact — Equipment | | |
| SPM | 270 | Cheering Crowd | Creature — Human Citizen | | |
| SPM | 271 | Cosmic Spider-Man | Legendary Creature — Spider Human Hero | | |
| SPM | 272 | Jackal, Genius Geneticist | Legendary Creature — Human Scientist Villain | | |
| SPM | 273 | Kraven the Hunter | Legendary Creature — Human Warrior Villain | | |
| SPM | 274 | Mister Negative | Legendary Creature — Human Villain | | |
| SPM | 275 | Superior Spider-Man | Legendary Creature — Spider Human Hero | | |
| SPM | 276 | Ultimate Green Goblin | Legendary Creature — Goblin Villain | | |
| SPM | 277 | Doc Ock's Tentacles | Artifact — Equipment | | |
| SPM | 278 | Interdimensional Web Watch | Artifact | | |
| SPM | 279 | Iron Spider, Stark Upgrade | Legendary Artifact Creature — Spider Hero | | |
| SPM | 280 | Peter Parker's Camera | Artifact | | |
| SPM | 281 | Rocket-Powered Goblin Glider | Artifact — Equipment | | |
| SPM | 282 | Oscorp Industries | Land | | |
| SPM | 283 | Urban Retreat | Land | | |
| SPM | 284 | Spider-Sense | Instant | | |
| SPM | 285 | Radioactive Spider | Creature — Spider | | |
| SPM | 286 | Gwenom, Remorseless | Legendary Creature — Symbiote Spider Hero | | |