| 2X2 | 241 | League Guildmage | Creature — Human Wizard | | |
| 2X2 | 242 | Legion's Initiative | Enchantment | | |
| 2X2 | 243 | Lightning Helix | Instant | | |
| 2X2 | 244 | Lord of Extinction | Creature — Elemental | | |
| 2X2 | 245 | Lotleth Troll | Creature — Zombie Troll | | |
| 2X2 | 246 | Lyev Skyknight | Creature — Human Knight | | |
| 2X2 | 247 | Magister Sphinx | Artifact Creature — Sphinx | | |
| 2X2 | 248 | Marchesa, the Black Rose | Legendary Creature — Human Wizard | | |
| 2X2 | 249 | Martial Glory | Instant | | |
| 2X2 | 250 | Master Biomancer | Creature — Elf Wizard | | |
| 2X2 | 251 | Master of Cruelties | Creature — Demon | | |
| 2X2 | 252 | Mathas, Fiend Seeker | Legendary Creature — Vampire | | |
| 2X2 | 253 | Mayael's Aria | Enchantment | | |
| 2X2 | 254 | The Mimeoplasm | Legendary Creature — Ooze | | |
| 2X2 | 255 | Mindwrack Liege | Creature — Horror | | |
| 2X2 | 256 | Mistmeadow Witch | Creature — Kithkin Wizard | | |
| 2X2 | 257 | Mizzix of the Izmagnus | Legendary Creature — Goblin Wizard | | |
| 2X2 | 258 | Muldrotha, the Gravetide | Legendary Creature — Elemental Avatar | | |
| 2X2 | 259 | Murkfiend Liege | Creature — Horror | | |
| 2X2 | 260 | Nicol Bolas, God-Pharaoh | Legendary Planeswalker — Bolas | | |
| 2X2 | 261 | Orzhov Pontiff | Creature — Human Cleric | | |
| 2X2 | 262 | Phyrexian Tyranny | Enchantment | | |
| 2X2 | 263 | Privileged Position | Enchantment | | |
| 2X2 | 264 | Prized Amalgam | Creature — Zombie | | |
| 2X2 | 265 | Prophetic Bolt | Instant | | |
| 2X2 | 266 | Psychic Symbiont | Creature — Nightmare Horror | | |
| 2X2 | 267 | Qasali Pridemage | Creature — Cat Wizard | | |
| 2X2 | 268 | Rafiq of the Many | Legendary Creature — Human Knight | | |
| 2X2 | 269 | River Hoopoe | Creature — Bird | | |
| 2X2 | 270 | Roon of the Hidden Realm | Legendary Creature — Rhino Soldier | | |
| 2X2 | 271 | Ruric Thar, the Unbowed | Legendary Creature — Ogre Warrior | | |
| 2X2 | 272 | Scab-Clan Giant | Creature — Giant Warrior | | |
| 2X2 | 273 | Sedraxis Specter | Creature — Specter | | |
| 2X2 | 274 | Sedris, the Traitor King | Legendary Creature — Zombie Warrior | | |
| 2X2 | 275 | Shattergang Brothers | Legendary Creature — Goblin Artificer | | |
| 2X2 | 276 | Sidisi, Brood Tyrant | Legendary Creature — Snake Shaman | | |
| 2X2 | 277 | Skullbriar, the Walking Grave | Legendary Creature — Zombie Elemental | | |
| 2X2 | 278 | Sprouting Thrinax | Creature — Lizard | | |
| 2X2 | 279 | Sultai Soothsayer | Creature — Snake Shaman | | |
| 2X2 | 280 | Supreme Verdict | Sorcery | | |
| 2X2 | 281 | Tariel, Reckoner of Souls | Legendary Creature — Angel | | |
| 2X2 | 282 | Teneb, the Harvester | Legendary Creature — Dragon | | |
| 2X2 | 283 | Tenth District Legionnaire | Creature — Human Soldier | | |
| 2X2 | 284 | Terminate | Instant | | |
| 2X2 | 285 | Thistledown Liege | Creature — Kithkin Knight | | |
| 2X2 | 286 | Thousand-Year Storm | Enchantment | | |
| 2X2 | 287 | Thraximundar | Legendary Creature — Zombie Assassin | | |
| 2X2 | 288 | Tower Gargoyle | Artifact Creature — Gargoyle | | |
| 2X2 | 289 | Ulasht, the Hate Seed | Legendary Creature — Hellion Hydra | | |
| 2X2 | 290 | Uril, the Miststalker | Legendary Creature — Beast | | |
| 2X2 | 291 | Varina, Lich Queen | Legendary Creature — Zombie Wizard | | |
| 2X2 | 292 | Villainous Wealth | Sorcery | | |
| 2X2 | 293 | Wasitora, Nekoru Queen | Legendary Creature — Cat Dragon | | |
| 2X2 | 294 | Wilt-Leaf Liege | Creature — Elf Knight | | |
| 2X2 | 295 | Winged Coatl | Creature — Snake | | |
| 2X2 | 296 | Wrenn and Six | Legendary Planeswalker — Wrenn | | |
| 2X2 | 297 | Zur the Enchanter | Legendary Creature — Human Wizard | | |
| 2X2 | 298 | Aether Vial | Artifact | | |
| 2X2 | 299 | Bloodforged Battle-Axe | Artifact — Equipment | | |
| 2X2 | 300 | Civic Saber | Artifact — Equipment | | |